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Impact of Chemotherapy Exposure and DNMT3A Variants on Tumor Mutation Burden in Advanced Colorectal Cancer

2025-10-23

Abstract excerpt

<title>Abstract</title> <p> Background This study aimed to analyze the impact of clinical and environmental factors and individual genetic variants on tumor mutation burden (TMB) in cases of advanced or recurrent colorectal cancer (CRC) for which comprehensive genomic profiling (CGP) was performed. Methods Fifty patients with advanced or recurrent CRC for whom CGP was conducted were included in this study. Data...

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Literature Corpus work
a02ae641-c72e-5df0-a609-4c0db7698361
DOI
10.21203/rs.3.rs-7483602/v1
Open publication

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Impact of Chemotherapy Exposure and DNMT3A Variants on Tumor Mutation Burden in Advanced Colorectal CancerDOI 10.21203/rs.3.rs-7483602/v1
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