Article

Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells <i>via</i> GSK3α-Dyn2-Bin1 Interplay

2021-08-24

Abstract excerpt

Insulin-induced translocation of glucose transporter 4 (GLUT4) to the plasma membrane of skeletal muscle is critical for postprandial glucose uptake; however, whether the internalization of GLUT4 into cells is also regulated by insulin signaling remains unclear. Here, we discover that the activity of dynamin-2 (Dyn2), pivotal GTPase catalyzing GLUT4 internalization, is regulated by insulin signaling in muscle cell...

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Identifiers and source

Literature Corpus work: d9367461-58bc-5753-bd60-296fe059abfe
DOI: 10.1101/2021.08.23.457303

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