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Article

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.

Nature communications - 4 May 2020

Quan Chao, Du Qian, Li Min, Wang Ruizhen, Ouyang Qian, Su Shu, Zhu Sangsang, Chen Qiaoli, Sheng Yang, Chen Liang, Wang Hong, Campbell David G, MacKintosh Carol, Yang Zhongzhou, Ouyang Kunfu, Wang Hong Yu, Chen Shuai

Abstract excerpt

Diabetic cardiomyopathy is a progressive disease in diabetic patients, and myocardial insulin resistance contributes to its pathogenesis through incompletely-defined mechanisms. Striated muscle preferentially expressed protein kinase (SPEG) has two kinase-domains and is a critical cardiac regulator. Here we show that SPEG is phosphorylated on Ser2461/Ser2462/Thr2463 by protein kinase B (PKB) in response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

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Identifiers

PMID: 32367034
DOI: 10.1038/s41467-020-16116-9
PMCID: PMC7198626

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