Article

Live cell GLUT4 translocation assay reveals <i>Per3</i> as a novel regulator of circadian insulin sensitivity in skeletal muscle cells

2025-02-16

Abstract excerpt

Type 2 Diabetes (T2D) is a growing global health concern, with skeletal muscle playing a central role in its pathology due to its role in postprandial glucose disposal. Insulin resistance in skeletal muscle often precedes T2D diagnosis and is linked to impaired GLUT4 trafficking. Additionally, circadian disruptions are increasingly recognized as contributors to metabolic dysfunction. We have shown that skeletal mu...

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Literature Corpus work: 017f8149-5d2c-5a7c-80ba-87096bf4f63c
DOI: 10.1101/2025.02.13.638110

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