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Article

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Nov 2011

Larson Erin B, Graham Danielle L, Arzaga Rose R, Buzin Nicole, Webb Joseph, Green Thomas A, Bass Caroline E, Neve Rachael L, Terwilliger Ernest F, Nestler Eric J, Self David W

Abstract excerpt

Chronic exposure to addictive drugs enhances cAMP response element binding protein (CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. Here, we used viral-mediated gene transfer to produce short- and long-term regulation of CREB activity in NAc shell of rats engaging in volitional cocaine...

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Source

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Identifiers

PMID: 22072694
DOI: 10.1523/JNEUROSCI.3070-11.2011
PMCID: PMC3229171

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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