Article

Rarγ -Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

2024-03-10

Abstract excerpt

Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial roles in directing body axis orientation and tissue differentiation, including in the reproductive system. However, a mechanistic understanding of how RA signaling promotes cell lineage identity in different tissues is often missing. Here, leveraging prostate organoid technology, we demonstrated that RA signaling orchestrates...

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Identifiers and source

Literature Corpus work: d23a9475-cd82-5700-90b5-934b792174be
DOI: 10.1101/2024.03.06.583256

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