Article

Vitamin D deficiency alters prostate epithelial differentiation and increases prostate cancer aggressiveness in ex vivo and in vivo models

2026-02-18

Abstract excerpt

<h4>ABSTRACT</h4> Here, we examined the consequences of biologically relevant vitamin D deficiency, a known risk factor for aggressive prostate cancer, using ex vivo and in vivo models. Phenotypic and single-cell RNA sequencing of mouse prostate organoids showed that vitamin D deficiency stunted luminal cell differentiation more than androgen deficiency, which is a known driver of prostate development. Mice fed a...

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Literature Corpus work: 932f0a8d-f7da-53e1-9ff1-b8e2e3f6cef3
DOI: 10.64898/2026.02.16.700850

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