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Article

Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.

Science (New York, N.Y.) - 4 Sept 2025

Eyunni Sanjana, Mannan Rahul, Zhang Yuping, Young Eleanor, Zhang Qiuyang, Luo Jie, Pang Matthew, Mahapatra Somnath, Tien Jean Ching-Yi, George James M, Jaber Mustapha, Hakkani Hamzah, Carson Sandra E, Todd Abigail J, Hosseini Noshad, Gondal Mahnoor, Rebernick Ryan J, Cao Xuhong, Su Fengyun, Wang Rui, Mehra Rohit, Li Jing, Cieslik Marcin, Chinnaiyan Arul M, Parolia Abhijit

Abstract excerpt

FOXA1 is altered in 10 to 40% of prostate cancers, yet its oncogenic mechanisms remain uncharacterized in vivo. We developed knock-in mouse models representing distinct classes of FOXA1 mutations. Histopathological and multiomic analyses of prostate tissues and organoids revealed that Class 1 mutations, in conjunction with p53 inactivation, drive androgen-dependent adenocarcinomas through coactivation of mTORC1/2...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40570057
DOI: 10.1126/science.adv2367
PMCID: PMC12326538

Genes

FOXA1
AR
KLF5

Provenance

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