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Article

The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression

17 Aug 2018

Abstract excerpt

Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARγ) are commonly reduced in prostate cancer (PCa). Therefore, we sought to establish the cellular and gene regulatory consequences of reduced RARγ expression, and determine RARγ regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reducing RARγ levels, rather...

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PMID: 30120411
DOI: 10.1038/s41388-018-0450-6

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