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The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

2025-10-08

Abstract excerpt

<title>Abstract</title> <p> The establishment of cell type–specific chromatin landscapes is essential for cellular identity, but how these landscapes are generated remains poorly understood. Here, we demonstrate that the chromatin remodeler SMARCA5 establishes epigenetic priming that is required for retinoic acid (RA)–induced differentiation in the male germline. Germ cell–specific deletion of <italic>Smarca5</...

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Literature Corpus work
e12e79d0-0786-5cdb-82e3-66c8f21c96eb
DOI
10.21203/rs.3.rs-7576931/v1
Open publication

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The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline DevelopmentDOI 10.21203/rs.3.rs-7576931/v1
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