Article

The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression

2017-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Expression levels of retinoic acid receptor gamma ( NR1B3 / RARG , encodes RARγ), are commonly reduced in prostate cancer (PCa). Therefore we sought to establish the cellular and gene regulatory consequences of reduced RARγ expression, and determine RARγ regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34787d3f-f6cc-5c96-8da2-1924b0fcf61e
DOI: 10.1101/198465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progressionDOI 10.1101/198465Read

The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progressionSemantic proximity Read

Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significanceSemantic proximity Read

Rarγ -Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancerSemantic proximity Read

Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cellsSemantic proximity Read

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancerSemantic proximity Read

Rare Cancer-Associated Mutations Target the AF1 Phosphoregulatory Domain of RARγSemantic proximity Read

Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesionSemantic proximity Read

PACT is requisite for prostate cancer cell proliferationSemantic proximity Read

Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phaseSemantic proximity Read

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer MetastasisSemantic proximity Read

High expression of RARG accelerates ovarian cancer progression by regulating cell proliferationSemantic proximity Read

Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental ProgressionSemantic proximity Read