Article

The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

2025-07-31

Abstract excerpt

The establishment of cell type–specific chromatin landscapes is essential for cellular identity, but how these landscapes are generated remains poorly understood. Here, we demonstrate that the chromatin remodeler SMARCA5 establishes epigenetic priming that is required for retinoic acid (RA)–induced differentiation in the male germline. Germ cell–specific deletion of Smarca5 results in a complete loss of different...

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Literature Corpus work: cf8f3b19-de3b-5bb5-bb45-29f1b5d91867
DOI: 10.1101/2025.07.29.667536

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