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Article

RARα1 control of mammary gland ductal morphogenesis and wnt1-tumorigenesis

1 Oct 2010

Abstract excerpt

INTRODUCTION: Retinoic acid signaling pathways are disabled in human breast cancer suggesting a controlling role in normal mammary growth that might be lost in tumorigenesis. We tested a single receptor isotype, RARα1, for its role in mouse mammary gland morphogenesis and MMTV-wnt1-induced oncogenesis. METHODS: The role of RARα1 in mammary morphogenesis was tested in RARα1-knockout (KO) mice and in mammary...

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PMID: 20923554
DOI: 10.1186/bcr2724

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