Article

FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity

2025-11-14

Abstract excerpt

Mutations in the pioneer transcription factor FOXA1, found in 10-40% of human prostate cancers, alter global chromatin accessibility and promote growth in prostate cells. Through analysis of a novel cohort of 874 primary and metastatic prostate tumors with somatic FOXA1 mutations, we confirm the high frequency of missense mutations (n=339) and indels (n=335) in the Wing2 region of the Forkhead domain, as well as f...

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Literature Corpus work: 82df7299-7306-5dd3-adba-92f00f8581e2
DOI: 10.1101/2025.11.13.688263

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