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Article

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.

Neurobiology of aging - 1 Jan 2015

Tozzi Alessandro, Sclip Alessandra, Tantucci Michela, de Iure Antonio, Ghiglieri Veronica, Costa Cinzia, Di Filippo Massimiliano, Borsello Tiziana, Calabresi Paolo

Abstract excerpt

To characterize the mechanisms underlying region- and age-dependent hippocampal synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing the Swedish-Indiana APP mutation. In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area but not in dentate gyrus (DG). At this age, long-term potentiation (LTP) was reduced selectively in...

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Source

Identifiers

PMID: 25104560
DOI: 10.1016/j.neurobiolaging.2014.07.002

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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