Article

The effect of CARD11 mutation and HBZ expression accelerated lymphoproliferative diseases and formed the pathological basis for adult T-cell leukemia/lymphoma

2022-02-01

Abstract excerpt

<title>Abstract</title> <p>Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling such as CARD11 have been detected in about 90% of patients. Utilizing mouse models with T cell-specific CARD11(E626K) expression and/or CD4+ T cell-spe...

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Literature Corpus work: d21ef8db-e9be-5107-863a-80a78648dcb8
DOI: 10.21203/rs.3.rs-1275667/v1

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