Article
Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2015
Knies Nathalie, Alankus Begüm, Weilemann Andre, Tzankov Alexandar, Brunner Kristina, Ruff Tanja, Kremer Marcus, Keller Ulrich B, Lenz Georg, Ruland Jürgen
Abstract excerpt
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-κB) activation, which is required for tumor cell survival. BCR-induced NF-κB activation requires caspase recruitment domain-containing protein 11 (CARD11), and CARD11 gain-of-function mutations are recurrently detected in human...
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