Article
RLTPR Q575E: A novel recurrent gain-of-function mutation in patients with adult T-cell leukemia/lymphoma.
European journal of haematology - 1 Feb 2021
Uchida Yuichiro, Yoshimitsu Makoto, Hachiman Miho, Kusano Shuichi, Arima Naosuke, Shima Kodai, Hayashida Maiko, Kamada Yuhei, Nakamura Daisuke, Arai Akihiko, Tanaka Yuetsu, Hara Hiromitsu, Ishitsuka Kenji
Abstract excerpt
OBJECTIVES: Adult T-cell leukemia/lymphoma (ATL) is an intractable T-cell malignancy caused by long-term infection with human T-cell leukemia virus type-1 (HTLV-1). While ATL pathogenesis has been associated with HTLV-1-derived oncogenic proteins, including Tax and HBZ, the contribution of genomic aberrations remains poorly defined. METHODS: To elucidate the genomic basis of ATL, whole exome sequencing was...
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