CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.

doi:10.1038/s42003-022-04284-x

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Article

CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.

Communications biology - 29 Nov 2022

Kameda Takuro, Shide Kotaro, Kamiunten Ayako, Kogure Yasunori, Morishita Daisuke, Koya Junji, Tahira Yuki, Akizuki Keiichi, Yokomizo-Nakano Takako, Kubota Sho, Marutsuka Kosuke, Sekine Masaaki, Hidaka Tomonori, Kubuki Yoko, Kitai Yuichi, Matsuda Tadashi, Yoda Akinori, Ohshima Takayuki, Sugiyama Midori, Sashida Goro, Kataoka Keisuke, Ogawa Seishi, Shimoda Kazuya

Abstract excerpt

Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling, such as CARD11, are detected in about 90% of patients. Utilizing mice expressing CD4+ T cell-specific CARD11(E626K) and/or CD4+ T cell-specific HBZ, namely CARD11(E626K)CD4-Cre...

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PMID: 36446869
DOI: 10.1038/s42003-022-04284-x
PMCID: PMC9709164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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