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Article

Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations.

Haematologica - 1 Dec 2024

Myers Caroline S, Williams Eli, Cornejo Carlos Barrionuevo, Pongas Georgios, Toomey Ngoc L, Sanches Jose A, Battistella Maxime, Mo Samuel, Pulitzer Melissa, Moskaluk Cristopher A, Bhagat Govind, Ofori Kenneth, Davick Jonathan J, Servitje Octavio, Miyashiro Denis, Climent Fina, Ringbloom Kimberley, Duenas Daniela, Law Calvin, Zambrano Sandro Casavilca, Malpica Luis, Beltran Brady E, Castro Denisse, Barreto Luciana, Brites Carlos, Chapman Jennifer R, Choi Jaehyuk, Gru Alejandro A, Ramos Juan C

Abstract excerpt

Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy driven by human T-cell leukemia virus type 1 (HTLV-1). Although patients from the Western hemisphere (Afro-Caribbean and South American) face worse prognoses, our understanding of ATLL molecular drivers derives mostly from Japanese studies. We performed multi-omic analyses to elucidate the genomic landscape of ATLL in Western cohorts. Recurrent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39113648
DOI: 10.3324/haematol.2024.285233
PMCID: PMC11609816

Genes

FOXO3
CARD11
DGKZ
GATA3
PTPN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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