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Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections.

2024-10-21

Abstract excerpt

<title>Abstract</title> <p>Respiratory virus infections are invariably accompanied by an increase in oxidative stress, characterised by elevated production of Reactive Oxygen Species (ROS) in the lung, which plays a pivotal role in both pathogenesis and host defence. Using a mouse model, neutrophil NADPH Oxidase 2 (Nox2) emerges as a key player, primarily responsible for generation of ROS during the early phases...

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Literature Corpus work
0ca2737a-31ec-58a6-b53c-cfb8cf1f60ed
DOI
10.21203/rs.3.rs-5145371/v1
Open publication

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Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections.DOI 10.21203/rs.3.rs-5145371/v1
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