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Article

Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.

Antioxidants & redox signaling - 1 Jan 2012

Joo Jung-Hee, Ryu Ji-Hwan, Kim Chang-Hoon, Kim Hyun Jik, Suh Mi-Sun, Kim Jin-Oh, Chung Seung Yeun, Lee Sang Nam, Kim Hwan Mook, Bae Yun Soo, Yoon Joo-Heon

Abstract excerpt

AIMS: Airway mucosa is constantly exposed to various airborne microbes, and epithelial host defense requires a robust innate immunity. Recently, it has been suggested that NADPH oxidase (NOX) isozymes serve functional roles in toll-like receptor (TLR)-mediated innate immune responses. However, the molecular mechanism between TLR and NOX-mediated reactive oxygen species (ROS) production in human airway mucosa has...

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Source

Identifiers

PMID: 21714724
DOI: 10.1089/ars.2011.3898

Genes

DUOX2
TLR5
MIP

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Related research

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Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.PMID 21714724Read ↗

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Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymesSemantic proximity Read ↗

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