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Article

Role of NADPH oxidase in host defense against aspergillosis.

Medical mycology - 1 Apr 2011

Grimm Melissa J, Vethanayagam R Robert, Almyroudis Nikolaos G, Lewandowski David, Rall Nicole, Blackwell Timothy S, Segal Brahm H

Abstract excerpt

NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20560866
DOI: 10.3109/13693786.2010.487077
PMCID: PMC5494985

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