Article

Adiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis

2024-06-26

Abstract excerpt

Although innate immunity is critical for antifungal host defense against the human opportunistic fungal pathogen Aspergillus fumigatus , potentially damaging inflammation must be controlled. Adiponectin (APN) is an adipokine produced mainly in adipose tissue that exerts anti-inflammatory effects in adipose-distal tissues such as the lung. We observed 100% mortality and increased fungal burden and inflammation in...

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Identifiers and source

Literature Corpus work: d21567a0-f8ac-584f-b773-ae27f82c3b2e
DOI: 10.1101/2024.06.24.600373

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