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Article

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1

23 Nov 2016

Abstract excerpt

Defects in a form of noncanonical autophagy, known as LC3-associated phagocytosis (LAP), lead to increased inflammatory pathology during fungal infection. Although LAP contributes to fungal degradation, the molecular mechanisms underlying LAP-mediated modulation of inflammation are unknown. We describe a mechanism by which inflammation is regulated during LAP through the death-associated protein kinase 1 (DAPK1)....

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PMID: 27889463
DOI: 10.1016/j.chom.2016.10.012

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