The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages.

doi:10.3389/fimmu.2018.00567

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Article

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages.

Frontiers in immunology - 1 Jan 2018

de Albuquerque Jose Antonio Tavares, Banerjee Pinaki Prosad, Castoldi Angela, Ma Royce, Zurro Nuria Bengala, Ynoue Leandro Hideki, Arslanian Christina, Barbosa-Carvalho Marina Uchoa Wall, Correia-Deur Joya Emilie de Menezes, Weiler Fernanda Guimarães, Dias-da-Silva Magnus Regios, Lazaretti-Castro Marise, Pedroza Luis Alberto, Câmara Niels Olsen Saraiva, Mace Emily, Orange Jordan Scott, Condino-Neto Antonio

Abstract excerpt

Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene (AIRE). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent Dectin-1 pathway. In this study, we further evaluated direct...

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Identifiers

PMID: 29666621
DOI: 10.3389/fimmu.2018.00567
PMCID: PMC5875531

Genes

AIRE
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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