Article

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

2025-06-11

Abstract excerpt

It is estimated that in excess of 10 million people around the globe are affected by severe asthma and fungal sensitisation (SAFS) or allergic bronchopulmonary aspergillosis (ABPA), severe asthma endotypes driven by hypersensitivity to environmentally ubiquitous fungal pathogens, primarily Aspergillus fumigatus . Here, we sought to define the immunological pathways underlying these allergic fungal airway diseases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08ccf4a6-0434-545d-9dad-72809d57513d
DOI: 10.1101/2025.06.09.658569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway diseaseDOI 10.1101/2025.06.09.658569Read

The Triad of Pathogenesis in Allergic Bronchopulmonary Aspergillosis: Interactions among <italic>Aspergillus fumigatus</italic>, Epithelium, and Immunity.Semantic proximity Read

Allergic bronchopulmonary aspergillosis.Semantic proximity Read

Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to <i>Aspergillus fumigatus</i> in cystic fibrosisSemantic proximity Read

Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epitheliumSemantic proximity Read

A murine model to study chronic airway fungal colonisation that recapitulates human diseaseSemantic proximity Read

Aspergillus spp. in Non-Cystic Fibrosis Bronchiectasis: Clinical Phenotypes, Molecular Endotypes, and Practical Management-A Narrative Review.Semantic proximity Read

Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype.Semantic proximity Read

Strain specific persistence in the murine lung of <i>Aspergillus fumigatus</i> conidia causes an Allergic Broncho-Pulmonary Aspergillosis-like disease phenotypeSemantic proximity Read

Broad remodeling of the pulmonary immune landscape occurs during IAPA with specific functional deficits of neutrophil subsetsSemantic proximity Read

Re-defining the unique roles for eosinophils in allergic respiratory inflammation.Semantic proximity Read

Immune response, diagnosis and treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis lung disease.Semantic proximity Read

Dual Organism Transcriptomics of Airway Epithelial Cells Interacting with Conidia of Aspergillus fumigatusSemantic proximity Read