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Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to <i>Aspergillus fumigatus</i> in cystic fibrosis

2024-12-03

Abstract excerpt

Aspergillus fumigatus ( Af ) is a major mould pathogen found ubiquitously in the air. It commonly infects the airways of people with cystic fibrosis (CF) leading to Aspergillus bronchitis or allergic bronchopulmonary aspergillosis. Resident alveolar macrophages and recruited neutrophils are important first lines of defence for clearance of Af in the lung. However, their contribution to the inflammatory phenotyp...

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Literature Corpus work
091c4ead-08a7-5f0d-b6db-426e597bf6dd
DOI
10.1101/2024.11.29.625998
Open publication

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Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to <i>Aspergillus fumigatus</i> in cystic fibrosisDOI 10.1101/2024.11.29.625998
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