Article
Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1.
Molecular biology of the cell - 1 Nov 2020
Boyle John M, Hennick Kelsey M, Regalado Samuel G, Vogan Jacob M, Zhang Xiaozhu, Collins Kathleen, Hockemeyer Dirk
Abstract excerpt
Telomere maintenance is essential for the long-term proliferation of human pluripotent stem cells, while their telomere length set point determines the proliferative capacity of their differentiated progeny. The shelterin protein TPP1 is required for telomere stability and elongation, but its role in establishing a telomere length set point remains elusive. Here, we characterize the contribution of the shorter...
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