Article

Citrullination of pyruvate kinase by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

2019-08-04

Abstract excerpt

CHD3 and CHD4 are mutually exclusive ATPase subunits of the Nucleosome Remodelling and Deacetylation (NuRD) complex that regulates gene expression. CHD4 is essential for growth of multiple patient derived melanoma xenografts and for breast cancer. Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of three arginines...

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Literature Corpus work: d1d34af4-229a-5ac3-8573-da082ec8c1d5
DOI: 10.1101/718486

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