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Article

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

27 Aug 2021

Abstract excerpt

Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PADI4) catalyzes the deimination of histone arginine residues to citrulline. Here, we demonstrate that PADI4 expression is induced by hypoxia in a HIF-dependent manner in breast cancer and hepatocellular carcinoma cells. PADI4, in turn, is recruited by...

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Adipose Tissue and Metabolism
Cancer, Hypoxia, and Metabolism
Cancer-related molecular mechanisms research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34452909
DOI: 10.1126/sciadv.abe3771

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