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Article

A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer.

Journal of medicinal chemistry - 23 May 2024

Zhu Di, Lu Yu, Yan Zhanchao, Deng Qian, Hu Bo, Wang Yinsong, Wang Wenjing, Wang Yanming, Wang Yuji

Abstract excerpt

Triple-negative breast cancer is a highly aggressive and heterogeneous breast cancer subtype characterized by early metastasis, poor prognosis, and high recurrence. Targeting histone citrullination-mediated chromatin dysregulation to induce epigenetic alterations shows great promise in TNBC therapy. We report the synthesis, optimization, and evaluation of a novel series of β-carboline-derived peptidyl arginine...

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Identifiers

PMID: 38728549
DOI: 10.1021/acs.jmedchem.4c00030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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