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In Silico Modelling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel Bioreactors

2026-04-26

Abstract excerpt

Human pluripotent stem cells (hPSCs) hold significant promise for regenerative medicine, yet optimizing their expansion in three-dimensional bioreactor systems remains challenging due to complex interactions between mechanical forces, metabolic constraints, and aggregate formation dynamics. This study developed and validated a mechanistic mathematical model to predict hPSC proliferation dynamics in vertical-wheel...

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Literature Corpus work
d1c9aa10-802b-5dfc-94ff-05d28b34b3c7
DOI
10.64898/2026.04.22.720266
Open publication

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In Silico Modelling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel BioreactorsDOI 10.64898/2026.04.22.720266
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