Article

Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System

2025-09-08

Abstract excerpt

<h4>Background</h4> Multiple protocols have been reported for the large-scale generation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in bioreactors using small molecules; however, no comparable bioreactor-based methods have been established using growth factors. This is despite evidence that differentiation with optimized concentrations of BMP4, Activin A, and bFGF offers finer control of car...

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Literature Corpus work: ca720009-5599-57ab-b9c3-72eb27b0b336
DOI: 10.1101/2025.09.07.674777

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