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Article

Expansion of 3D human induced pluripotent stem cell aggregates in bioreactors: Bioprocess intensification and scaling-up approaches.

Journal of biotechnology - 20 Mar 2017

Abecasis Bernardo, Aguiar Tiago, Arnault Émilie, Costa Rita, Gomes-Alves Patricia, Aspegren Anders, Serra Margarida, Alves Paula M

Abstract excerpt

Human induced pluripotent stem cells (hiPSC) are attractive tools for drug screening and disease modeling and promising candidates for cell therapy applications. However, to achieve the high numbers of cells required for these purposes, scalable and clinical-grade technologies must be established. In this study, we use environmentally controlled stirred-tank bioreactors operating in perfusion as a powerful tool...

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Identifiers

PMID: 28131858
DOI: 10.1016/j.jbiotec.2017.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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