Back to search

Article

Addressing Bioreactor hiPSC Aggregate Stability, Maintenance and Scaleup Challenges Using a Design of Experiment Approach

2023-11-23

Abstract excerpt

<title>Abstract</title> <p>Background Stem cell-derived therapies hold the potential for treatment of regenerative clinical indications. Static culture has a limited ability to scale up thus restricting its use. Suspension culturing can be used to produce target cells in large quantities, but also presents challenges related to stress and aggregation stability. Methods Utilizing a design of experiments (DoE) ap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
13aeb1d8-97f7-5592-b618-8722d13ec0ba
DOI
10.21203/rs.3.rs-3500780/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Addressing Bioreactor hiPSC Aggregate Stability, Maintenance and Scaleup Challenges Using a Design of Experiment ApproachDOI 10.21203/rs.3.rs-3500780/v1
Robust Bioprocess Design and Evaluation of Commercial Media for the Serial Expansion of Human Induced Pluripotent Stem Cell Aggregate Cultures in Vertical-Wheel BioreactorsSemantic proximity
In Silico Modelling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel BioreactorsSemantic proximity
Overcoming Bioprocess Bottlenecks in the Large-Scale Expansion of High Quality hiPSC Aggregates in Vertical-Wheel Stirred Suspension BioreactorsSemantic proximity
Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor SystemSemantic proximity
Expansion of 3D human induced pluripotent stem cell aggregates in bioreactors: Bioprocess intensification and scaling-up approaches.Semantic proximity
Suspension culture on microcarriers and as aggregates enables expansion and differentiation of pluripotent stem cells (PSCs)Semantic proximity
Mesenchymal and induced pluripotent stem cell–based therapeutics: a comparisonSemantic proximity
Suspension culture improves iPSC expansion and pluripotency phenotype.Semantic proximity
Dynamic suspension culture enhances scalable maturation of hiPSC-derived cartilage organoids for regenerative medicineSemantic proximity
Matrix-free human pluripotent stem cell manufacturing by seed train approach and intermediate cryopreservationSemantic proximity
Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic CharacterizationSemantic proximity
Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing PotentialSemantic proximity
Select a neighboring publication to make it the new centre.