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Matrix-free human pluripotent stem cell manufacturing by seed train approach and intermediate cryopreservation

25 Mar 2024

Abstract excerpt

Abstract Background Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture (three-dimensional; 3D) of hPSCs in stirred tank bioreactors (STBRs) has enormous potential for fuelling these cell demands. In this study, the efficient long-term matrix-free suspension...

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PMID: 38528578
DOI: 10.1186/s13287-024-03699-z

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