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Article

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics

2 Dec 2011

Abstract excerpt

We present a predictive bioprocess design strategy employing cell- and molecular-level analysis of rate-limiting steps in human pluripotent stem cell (hPSC) expansion and differentiation, and apply it to produce definitive endoderm (DE) progenitors using a scalable directed-differentiation technology. We define a bioprocess optimization parameter (L; targeted cell Loss) and, with quantitative cell division...

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PMID: 22139975
DOI: 10.1002/bit.24375

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