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Inhibition of the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells

2020-03-31

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma, the most aggressive brain cancer, often recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. Here, we show that patient-derived GSCs, but not normal astrocytes, are highly sensitive to lysis by healthy allogeneic natural killer (NK) cells in vitro . In contrast, single cell analysis of autologous, tissue infiltrating NK cells isolated from surgica...

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Literature Corpus work
d19af8cf-ec26-5ce3-96e5-6f338d3b9181
DOI
10.1101/2020.03.30.016667
Open publication

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Inhibition of the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cellsDOI 10.1101/2020.03.30.016667
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