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Article

NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Gras Navarro Andrea, Kmiecik Justyna, Leiss Lina, Zelkowski Mateusz, Engelsen Agnete, Bruserud Øystein, Zimmer Jacques, Enger Per Øyvind, Chekenya Martha

Abstract excerpt

Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells were more potent killers, notwithstanding the absence of inhibitory killer Ig-like receptor (KIR)-HLA ligand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25381437
DOI: 10.4049/jimmunol.1400859
PMCID: PMC4259203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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