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Article

Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing

21 Jul 2022

Abstract excerpt

Objective: NK cells play crucial roles in the immune defense mechanisms against viral infections and transformed cells. However, the developmental progression, transcriptomic landscape, and functional subtypes of liver NK cells are not well defined. Hepatocellular carcinoma (HCC) accounts for approximately 80% of primary liver cancer worldwide, yet the biological characteristics of NK cells in the HCC environment...

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PMID: 35856557
DOI: 10.20892/j.issn.2095-3941.2022.0050

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