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Article

HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells.

Journal of neuroimmunology - 15 Sept 2012

Wolpert Fabian, Roth Patrick, Lamszus Katrin, Tabatabai Ghazaleh, Weller Michael, Eisele Günter

Abstract excerpt

Cancer stem cells are an attractive target for immunotherapeutic approaches to glioblastoma. However, an immune inhibitory phenotype of cells currently classified as "glioma-initiating cells" (GIC) might counteract recognition by immune effector cells. Here, we investigate the contribution of the non-classical MHC molecule HLA-E to the immunosuppressive phenotype of GIC. HLA-E is expressed in GIC lines and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22688424
DOI: 10.1016/j.jneuroim.2012.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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