Article

An RNAi screen in <i>C. elegans</i> for genes that play a role in secretion and cleavage of VAPB MSP domain

2021-01-03

Abstract excerpt

VAPB (VPR-1 in C. elegans ) is a type-II ER transmembrane protein whose N-terminal Major Sperm Protein domain (MSPd) is cleaved and secreted. Mutations in the MSPd of human VAPB cause impaired secretion and are associated with Amyotrophic Lateral Sclerosis (ALS). In C. elegans , the secreted MSPd signals non-cell-autonomously to regulate striated muscle mitochondrial morphology and gonad development. As VAPB/VPR...

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Literature Corpus work: d18ac23b-0a54-51b2-8989-3326eb749379
DOI: 10.1101/2021.01.02.425092

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