Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1.

Development (Cambridge, England) - 15 Jun 2017

Schultz Jessica, Lee Se-Jin, Cole Tim, Hoang Hieu D, Vibbert Jack, Cottee Pauline A, Miller Michael A, Han Sung Min

Abstract excerpt

The major sperm protein domain (MSPd) has an extracellular signaling function implicated in amyotrophic lateral sclerosis. Secreted MSPds derived from the C. elegans VAPB homolog VPR-1 promote mitochondrial localization to actin-rich I-bands in body wall muscle. Here we show that the nervous system and germ line are key MSPd secretion tissues. MSPd signals are transduced through the CLR-1 Lar-like tyrosine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin-Related Protein 2-3 Complex
Share to Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Mitochondria, Muscle

Share to Motor Neurons

Share to Protein Domains

Share to Sarcolemma

Share to SMN Complex Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28634272
DOI: 10.1242/dev.152025
PMCID: PMC5482996

Genes

VAPB
ARX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1.PMID 28634272Read ↗

An RNAi screen in <i>C. elegans</i> for genes that play a role in secretion and cleavage of VAPB MSP domainSemantic proximity Read ↗

The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously.Semantic proximity Read ↗

Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.Semantic proximity Read ↗

<i>VPS13D</i> mutations affect mitochondrial homeostasis and locomotion in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging.Semantic proximity Read ↗

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal DiseaseSemantic proximity Read ↗

<i>Drosophila</i> Short stop as a paradigm for the role and regulation of spectraplakinsSemantic proximity Read ↗

Regulation of Mechanosensor PIEZO Channel Trafficking in <i>C. elegans</i> GermlineSemantic proximity Read ↗

Broadly Conserved TMEM-131 Family Proteins in Collagen Production and Secretory Cargo TraffickingSemantic proximity Read ↗

VPS13D Mutations Affect Mitochondrial Homeostasis and Locomotion in Caenorhabditis elegansSemantic proximity Read ↗

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversionSemantic proximity Read ↗

VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.