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Article

Mitigating Motor Neuronal Loss in C. elegans Model of ALS8.

Scientific reports - 14 Sept 2017

Zhang Wendy, Colavita Antonio, Ngsee Johnny K

Abstract excerpt

ALS8 is a late-onset familial autosomal dominant form of Amyotrophic Lateral Sclerosis (ALS) caused by a point mutation (P56S) in the VAPB gene (VAMP associated protein isoform B). Here, we generated two C. elegans models of the disease: a transgenic model where human VAPB wild-type (WT) or P56S mutant was expressed in a subset of motor neurons, and a second model that targeted inducible knockdown of the worm's...

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Source

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Identifiers

PMID: 28912432
DOI: 10.1038/s41598-017-11798-6
PMCID: PMC5599522

Genes

VAPB

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