Article

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion

2023-04-14

Abstract excerpt

<title>Abstract</title> <p>VAMP-associated protein (VAP) is a type II integral transmembrane protein at the endoplasmic reticulum (ER). Mutations in human VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS). The N-terminal major sperm protein (MSP) domain of VAPB (<italic>Drosophila</italic> Vap33) is cleaved, secreted, and acts as a signaling ligand for several cell-surface receptors. Although extr...

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Literature Corpus work: c30b31b5-8f76-5d99-8d21-30981407b72f
DOI: 10.21203/rs.3.rs-2757221/v1

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