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Article

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion.

Nature communications - 10 Oct 2024

Kamemura Kosuke, Kozono Rio, Tando Mizuki, Okumura Misako, Koga Daisuke, Kusumi Satoshi, Tamai Kanako, Okumura Aoi, Sekine Sayaka, Kamiyama Daichi, Chihara Takahiro

Abstract excerpt

VAMP-associated protein (VAP) is a type IV integral transmembrane protein at the endoplasmic reticulum (ER). Mutations in human VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS). The N-terminal major sperm protein (MSP) domain of VAPB (Drosophila Vap33) is cleaved, secreted, and acts as a signaling ligand for several cell-surface receptors. Although extracellular functions of VAPB are beginning to...

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PMID: 39389966
DOI: 10.1038/s41467-024-53097-5
PMCID: PMC11467184

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