Article

Broadly Conserved TMEM-131 Family Proteins in Collagen Production and Secretory Cargo Trafficking

2019-10-05

Abstract excerpt

Collagen is the most abundant protein in animals. Its dysregulation contributes to ageing and human disorders including tissue fibrosis in major organs. How premature collagens in the endoplasmic reticulum (ER) assemble and route for secretion remains molecularly undefined. From an RNAi screen, we identified an uncharacterized C. elegans gene tmem-131, deficiency of which impairs collagen production and activate...

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Literature Corpus work: d10643d2-92f6-593c-8bbf-6dd1c53855ce
DOI: 10.1101/794842

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