Article

SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII Vesicles

2020-07-16

Abstract excerpt

Fibrosis of various tissues is a typical disease caused by excessive production and secretion of extracellular matrix. We used Caenorhabditis elegans to investigate the formation of large transport vesicles to understand collagen secretion, a critical factor in fibrosis formation. The suro-2 mutant displays obvious defects in collagen secretion and cuticle structure including a rupture phenotype in early adults. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a690bdb9-efd2-5d5a-87e2-f6d3ff6874cd
DOI: 10.21203/rs.3.rs-35924/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII VesiclesDOI 10.21203/rs.3.rs-35924/v1Read

Broadly Conserved TMEM-131 Family Proteins in Collagen Production and Secretory Cargo TraffickingSemantic proximity Read

Structural and physiological functions of Caenorhabditis elegans epidermisSemantic proximity Read

Caenorhabditis elegans exoskeleton collagen COL-19: an adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology.Semantic proximity Read

An RNAi screen in <i>C. elegans</i> for genes that play a role in secretion and cleavage of VAPB MSP domainSemantic proximity Read

Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion.Semantic proximity Read

Structures and functions of collagens in Caenorhabditis elegans.Semantic proximity Read

The Caenorhabditis elegans ERp60 Homolog Protein Disulfide Isomerase-3 Has Disulfide Isomerase and Transglutaminase-like Cross-linking Activity and Is Involved in the Maintenance of Body MorphologySemantic proximity Read

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.Semantic proximity Read

The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.Semantic proximity Read

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in <i>Caenorhabditis elegans</i>Semantic proximity Read

Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.Semantic proximity Read

Caenorhabditis elegans dpy-14: an essential collagen gene with unique expression profile and physiological roles in early development.Semantic proximity Read