Article

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

2020-12-09

Abstract excerpt

The choroid plexus (ChP) secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the ChP epithelium (ChPe) arises from the Wnt -expressing cortical hem. Embryonic mouse and human ChPe both express nuclear β-CATENIN, a canonical Wnt signaling pathway effector, indicating that this pathway is active during ChPe development. Point mutations in human β-CATENI...

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Literature Corpus work: d174722e-26f0-5304-9c5e-f594741cacbe
DOI: 10.1101/2020.12.08.415588

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